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In order to have proper bone health, it takes a lot of focus and a lot of nutrients. Bone health is not only an important aspect when it comes to our structure but to our overall health in general. Our bones make and house bone marrow. Bone marrow is where every single blood cell in the body gets created. Without proper bone health, we see dysfunction in our blood, tissues, and other organ systems. Our genes have been associated with:

calcium homeostasis 
hormonal dysfunctional 
osteoblast and osteoclast development and regulation
cartilage matrix metabolism 
lipoprotein metabolism 

Lifestyle and nutrition have a large impact on these genes as osteoblasts are driven out of control with sleep deprivation, stress, poor nutrition, too much caffeine (this will drive calcium into the urine, where it is not able to be used by the body), a lack of exercise, too much exercise, and inflammation.