How Inflamm-aging and Body Composition Influences Women’s Health
Women’s health encompasses a multitude of factors that are carefully orchestrated by hormones. In turn, hormones can be produced by different glands and tissues, which gives them varied functions. Furthermore, production, transportation, sensitivity, and detoxification can be modulated by various factors; among them, body composition and aging play a determinant role. As the years roll, and that is something we cannot stop, we need to figure out how to modulate our aging process to maintain our female patient’s health. Understanding hormonal metabolism and how to promote hormonal production, transportation, sensitivity, and detoxification, we can connect the dots between the influence of body composition and anti-aging factors that contribute to women’s health.
Women’s health is an extensive, multifactorial mechanism that several lifestyle changes can promote. This article will discuss the importance of body composition, mitochondrial function, and muscle mass and their effect on menopausal women.
Inflamm-aging, mitochondrial dysfunction a women’s health
The concept of inflamm-aging pertains to the mechanism of elevated inflammatory cytokines and oxidative stress response that associates with mitochondrial dysfunction. Interestingly, mitochondrial dysfunction and chronic inflammation interdependent. Besides this, inflamm-aging results in a wide array of reactions involving elevated levels of pro-inflammatory cytokines that promote chronic diseases.
Do immune reactions ignite inflamm-aging?
Due to one particular factor, an immune response is caused by circulating cell-free mitochondrial DNA (mtDNA). Furthermore, mtDNA released due to cellular stress binds to cytoplasmatic pattern recognition receptors (PRRs) responsible for the generation of mitochondrial damage-associated molecular patterns (DAMPs).
Aging, hormonal changes, and muscle mass.
Menopause is a breaking point in defining women’s health. This condition relates to hormonal changes consistent with ovarian aging. Indeed, an increase in serum follicle-stimulating hormone (FSH) combined with decreased estradiol concentrations promotes a millie where muscle mass and bone density decline.
The hormonal changes that define the menopause stage lead to bone loss, increased bone turnover, and less bone formation. Furthermore, muscle loss has a tight association with mitochondrial function, oxidative capacity, and increased pro-inflammatory cytokines. Therefore the combination of hormonal changes and mitochondrial dysfunction in a pro-inflammatory milieu promotes age-related musculoskeletal issues in women.
But why is this so important? Mobility and structure are critical factors that ensure well-being. On the other hand, altered body composition consistent with excessive body fat coincides with an increased risk of all-cause mortality, disability, and institutionalization.
The biochemistry behind reduced bone density and reduced bone mass
Estrogen is an integral modulator in skeletal growth and maintenance. Specifically for women’s health, a decrease in estrogen levels leads to increased bone resorption and affects mechanosensitivity. On the other hand, average estrogen production and levels reduce proresorption cytokines.
Another critical factor about mechanosensitivity is the interplay between exercise and estrogen receptor alpha (ER-a) at a cellular level. Furthermore, ER-a is essential for osteogenesis, but the function and number of this receptor seem to stall or decrease during menopause. Therefore, the signal of the mechanical load induced by exercise loses potential, which results in no osteogenic response but reduced bone density.
Bone density and muscle mass are crucial for the structure that is the cornerstone of women’s health. While simple lifestyle changes, like exercise, can promote better bone density and muscle mass growth, overdoing it may be detrimental to these tissues. Therefore, promoting a smooth transition from premenopause to menopause is essential to keep hormonal-mediated osteogenesis. Furthermore, understanding the patient’s clinical history and determining the dietary, activity, and supplementation needed to promote her well-being is step one towards better women’s health.- Ana Paola Rodríguez Arciniega, MS
Chen, Y. C., Lin, W. C., Cheng, T. T., Chen, J. F., Yu, S. F., & Hsu, C. Y. (2020). Lower Central Fat Increase Risk of One-Year Muscle Mass Loss in Menopausal Women. Mediators of inflammation, 2020, 4650318. https://doi.org/10.1155/2020/4650318
Lang T. F. (2011). The bone-muscle relationship in men and women. Journal of osteoporosis, 2011, 702735. https://doi.org/10.4061/2011/702735
Additional Online Links & Resources (Available 24/7)
Online Appointments or Consultations: https://bit.ly/Book-Online-Appointment
Online Physical Injury / Accident Intake Form: https://bit.ly/Fill-Out-Your-Online-History
Online Functional Medicine Assessment: https://bit.ly/functionmed
The information herein on " How Inflamm-aging and Body Composition Influences Women's Health " is not intended to replace a one-on-one relationship with a qualified health care professional, licensed physician, and is not medical advice. We encourage you to make your own health care decisions based on your research and partnership with a qualified health care professional. Our information scope is limited to chiropractic, musculoskeletal, physical medicines, wellness, sensitive health issues, functional medicine articles, topics, and discussions. We provide and present clinical collaboration with specialists from a wide array of disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system. Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and support, directly or indirectly, our clinical scope of practice.* Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.
We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.