Nutrigenetics: Lactose Intolerance and Genetic Expression

For those who have lactose intolerance, the LCT gene transcription is reduced, leading to a low level of lactase. To turn off LCT it involves blocking an activator or turning up a repressor. In fact, it is theorized that lactase persistence is a human evolutionary adaptation to drinking milk from domesticated animals. The mutation in the gene started to appear around the same time as the domestication of cattle.

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