Gluten-related intolerances such as gluten sensitivity or celiac disease need to be addressed as undiagnosed celiac disease has been associated with a nearly 4-fold increase risk of death.  Gluten disorders show their presence in symptoms such as weight loss, bloating, flatulence, abdominal pain, iron deficiencies, skin disorders such as rashes, has an association with type 1 diabetes and results in abnormal liver function tests. 
For patients who are experiencing unexplained autoimmunity, unexplained neurological problems, uncomfortable GI symptoms, skin rashes, and unexplained depression, practitioners should think of gluten!