Insulin resistance is linked to major health conditions such as: obesity, prediabetes, diabetes, hypertension (high blood pressure), artery disease, cancer, arthritis, and neurodegenerative diseases. To reduce your chances of insulin resistance, take the steps to make positive changes in your lifestyle. Some simple steps include reducing your intake of sugary drinks and only drinking water, exercising regularly, and cutting out sugar, carbs, and foods with a high glycemic index.