A common symptom of sciatica is radiating/spreading pain running down the leg. However, the leg pain could be something to do with the blood vessels. If the pain travels from the low back to the hip, through the buttocks, down the leg, and into the foot, then more than likely it is sciatica. However, sciatica is just one condition that causes leg pain; other causes of leg pain include:

  • Bone spurs
  • Herniated disc
  • Arthritis
  • All can irritate the sciatic nerve causing sciatica.

The vascular system, also called the circulatory system, comprises the vessels that circulate blood and lymph throughout the body. Problems with the vascular system are a less common cause of leg pain but can be severe. Therefore, it is vital to learn to tell the difference.

Pain Running Down The Leg

Deep Vein Thrombosis

Deep vein thrombosis – DVT happens when a blood clot forms in a deep vein in the body and not the superficial veins just under the skin. The legs’ deep veins are susceptible to clotting. The formation of a clot can happen:

  • After surgery
  • From an accident
  • When recovering, bed resting and not moving.
  • When the body is in the same position for a long time with little to no movement, like a long plane ride.
  • On long plane rides, try to get up and walk around every hour. If unable to walk, do three sets of 20 reps of heel-to-toe exercises every hour.

Deep vein thrombosis can cause leg pain or swelling but can also present without causing any symptoms. Other risk factors include:

Blood Clots

Three main factors place individuals at risk for blood clots. They are:


  • This is when the blood is more prone to clotting. This can occur through:
  • Genetics
  • Medications
  • Pregnancy
  • Kidney disease
  • Trauma

Venous stasis

  • This is when blood flow circulation is slower than it should be. This usually happens from:
  • Sedentary lifestyle
  • Heart conditions
  • Obesity
  • Smoking
  • Clotting disorders

Vascular Trauma

  • Blunt or penetrating injury to the blood vessel and/or its walls.

Pain running down the leg from a blood clot feels like:

  • Tightness
  • Cramping soreness
  • Throbbing
  • Possible warmth
  • Swelling.

Blood clots and sciatica are reported to feel relatively different. The pain from a blood clot does not spread out and does not extend from or to the back. Sciatica does not cause swelling, redness, and warmth. If a doctor suspects a blood clot is causing the pain, they will order an ultrasound to confirm the diagnosis. If it is deep vein thrombosis, blood thinners could be recommended for three to six months.

  • A doctor may recommend aspirin, which can help in the prevention of blood clots.
  • Compression stockings/socks could also be recommended.
  • In some cases, the clot may have to be surgically removed.

Vascular Conditions and Pain Running Down The Leg

Other blood vessel conditions that can cause individuals to believe they have sciatica include:

Peripheral artery disease – PAD

This often presents in individuals with diabetes or who smoke. It causes pain in the calf area but does not radiate throughout the leg. The pain usually presents with physical effort movement. If the pain occurs when at rest, this could be a serious medical emergency. Peripheral artery disease is a chronic condition that can worsen if lifestyle changes are not made to reduce risk factors.

Acute limb ischemia

This condition can cause leg pain, but not the same as sciatica. What happens is the leg is not receiving blood, causing:

  • Intense pain in the extremity
  • Change in the color of the skin
  • Numbness
  • Weakness
  • Loss of a pulse

This vascular condition is a medical emergency and requires immediate treatment.

Acute compartment syndrome

This can happen after some kind of trauma to the leg.

  • The pain is acute, with the leg swelling up and a building up of tight pressure.
  • It usually affects the lower part of the leg.
  • This condition can also cause:
  • Numbness
  • Tingling
  • Visible swelling
  • Bruising

It is considered a medical emergency and needs to be treated quickly to avoid complications.

Varicose veins

Varicose veins can cause some pain running down the leg and/or aching, but the discomfort is not as intense. Treatment has come a long way, is less invasive, and includes:

  • Compression stockings, including prescription socks/stockings
  • Laser treatments
  • Minimally invasive procedures
  • Not staying on the feet too much
  • Elevating the legs
  • Maintaining an ideal weight can help

Vascular Disorder Prevention

Healthy lifestyle habits are recommended to keep the vascular system operating correctly. This includes:

Sciatica Treatment

If it is sciatica, fortunately, most cases go away on their own, but if treatment is needed, it is recommended to start with conservative treatments such as:

  • Chiropractic
  • Physical therapy
  • Anti-inflammatory medication
  • Muscle relaxants
  • Corticosteroid injections
  • In severe cases, surgery like a microdiscectomy or laminectomy will be performed to relieve pressure on the sciatic nerve.

Body Composition

Why might blood pressure be different when measuring on each arm?

The heart sits just to the left of the midline in the chest cavity. The aorta is the largest blood vessel in the body. It leaves through the left side of the heart and transports blood to a network of blood vessels that branch out, supplying the body with oxygen and nutrients. The arteries that branch off the aorta and go to the left and right sides of the body are different.

On the right, the brachiocephalic trunk comes off the aorta and splits into the right common carotid artery and right subclavian artery. The left common carotid and left subclavian arteries branch directly off the aorta. The differences mean that the risk for arterial thrombosis is not the same for the right and left subclavian arteries. Arterial thrombosis causes the blood vessels to become stiff, causing obstruction over time and is more likely to happen in the left subclavian than in the right. The difference in arterial branching affects blood pressure measurements on the left and right arms. The blood vessels are surrounded by:

  • Muscle
  • Fat
  • Connective tissue

When muscles place pressure on the blood vessels around the heart, it can cause short-term turbulence changes that can affect blood pressure.


American Heart Association. Atherosclerosis and cholesterol. www.heart.org/en/health-topics/cholesterol/about-cholesterol/atherosclerosis

American Heart Association. What is excessive blood clotting (Hypercoagulation?) www.heart.org/en/health-topics/venous-thromboembolism/what-is-excessive-blood-clotting-hypercoagulation

Centers for Disease Control and Prevention. What is venous thromboembolism? www.cdc.gov/ncbddd/dvt/facts.html

Cleveland Clinic. Compartment syndrome. my.clevelandclinic.org/health/diseases/15315-compartment-syndrome

Mayo Clinic. Deep vein thrombosis overview. www.mayoclinic.org/diseases-conditions/deep-vein-thrombosis/symptoms-causes/syc-20352557

Mayo Clinic. Sciatica. www.mayoclinic.org/diseases-conditions/sciatica/diagnosis-treatment/drc-20377441

Mayo Clinic. Sciatica overview. www.mayoclinic.org/diseases-conditions/sciatica/symptoms-causes/syc-20377435

Mayo Clinic. Varicose veins. www.mayoclinic.org/diseases-conditions/varicose-veins/diagnosis-treatment/drc-20350649

Obara, Hideaki et al. “Acute Limb Ischemia.” Annals of vascular diseases vol. 11,4 (2018): 443-448. doi:10.3400/avd.ra.18-00074

ScienceDirect. (n.d.) “Virchow’s Triad.” www.sciencedirect.com/topics/medicine-and-dentistry/virchows-triad


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