The immune system is one of the hardest working systems in the body. It is constantly working in the background, searching the body for bacterias and any potentially harmful pathogens. The first attacker in the line of defense is secretory IGA (SIgA). SIgA is the predominant immunoglobulin that is produced in the lining of the gut. 

SIgA Hard At Work 

Considering that the majority of the immune system is housed in the gut, the intestinal mucosa has to be able to recognize pathogens and other foreign objects to effectively keep them out. As previously mentioned, the first one on the scene is SIgA. This immunoglobulin differs from the other immunoglobulins the body produces (IgE, IgG, and IgM) in the way that it does not target a specific invader. IgA attacks all harmful antigens that enter the body, such as toxins, pathogenic bacteria, and viruses. This allows the interaction of negative substances to come into minimal contact with the epithelial surface of the gut. Additionally, SIgA does not cause the body to have an inflammatory response. 

The other functions of SIgA include trapping mucus, neutralizing enzymes and other toxins, inhibiting the adherence of pathogens, having interaction with antimicrobial factors like lactoferrin, all while being tolerant of the friendly flora. 

The Impact of Stress on SIgA and Our Immune Response 

During times of chronic stress, SIgA is decreased but during times of acute stress saliva testing shows an increase in SIgA. During these times of chronic stress, although SIgA is depressed, cortisol levels increase. 

High levels of SIgA is found in test results from those who have chronic infections and many hypersensitivities. The immune system in those with chronic infections is overloaded, leading to the production of excess inflammation. 

Low levels of SIgA generally represents nutrient deficiencies and malabsorptions. These individuals are more susceptible to food allergies. 

A test we use to check for food sensitivities and antibodies is the IgG4 by Genova:  

Improving SIgA

Any type of infection will lower SIgA. It is important to note that other factors that reduce SIgA include stress, a poor diet containing low levels of nutrients, genetics, the integrity of your gut lining, and age. 

Helping your body improve SIgA levels is important. Vitamin A is a critical component to properly restore the lining in your gut. Another supplement to help increase your level of SIgA is zinc coupled with vitamin A, and L-Glutamine. 

A strong immune system is what keeps us healthy, active, and able to experience more! Understanding where the immune system is housed and ways to help your first line of defense are critical in the supplements you take and diet you follow. Another important factor is stress. Reduce the presence of stress in your life and practice activities like yoga and meditation. This will help reduce the cortisol levels throughout your body, which is responsible for the overproduction of SIgA. -Kenna Vaughn, Senior Health Coach 



Grisanti, Ronald. “Secretory IgA Testing .” Functional Medicine University. 2020, www  .cfm .

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.  



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The information herein on "Our Body's Natural Immune Defense" is not intended to replace a one-on-one relationship with a qualified health care professional or licensed physician and is not medical advice. We encourage you to make healthcare decisions based on your research and partnership with a qualified healthcare professional.

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Our information scope is limited to Chiropractic, musculoskeletal, physical medicines, wellness, contributing etiological viscerosomatic disturbances within clinical presentations, associated somatovisceral reflex clinical dynamics, subluxation complexes, sensitive health issues, and/or functional medicine articles, topics, and discussions.

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We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez, DC, or contact us at 915-850-0900.

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